PRP treatment is not applicable in some cases. It is not applied during pregnancy and lactation. It is not suitable for PRP if the person has the possibility of autoimmune disease, tumour or metastasis. Also, thrombocytopenia, hypofibrinogenemia, sepsis cases, anticoagulant treatment is not applied in the case. In some cases, PRP treatment is postponed. PRP treatment is postponed for people who have had acute infections and who are taking antibiotics.